Bottom of the cassette, noisier.

I run Ultegra 6700. Now the summer is here I am using the bottom of the cassette more often. I have noted that there is more 'metallic' noise while running these gears whilst on the large chainring. It sounds like chain rub on the front deraillieur, but it is not. I assumed it was because they aren't used as often and so replaced the chain at 1500 miles. The cassette was replaced 1500 miles ago. However, it is still 'chatty' at the bottom of the cassette. The bike is highly maintained and the gears are tuned and adjusted correctly. Any thoughts please.
Team Madison Genesis Volare & Condor Super Acciaio
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Just back from the LBS with a 'true' technician'. He says 'chill'. 'tis normal, especially on sprockets that are less used. As a note, I use C3 Ceramic Wet Lube every 150 miles.
Back home now, increasing my medication.
Answer is don't cross chain so much
Please read OP again.