Priority when choosing a new frame?

in Road general
So, currently own a trek domane in size 54 and a medium giant contend sl2 disc in medium. The contend is more comfortable in terms of riding position but the isospeed system on the domane is lush however, on mine it’s only on the back so I’ve been looking out for a newer frame with front isospeed too. I’ve had a look at a geometry chart (seen a nice domane sl5 frame on eBay in size 56) to see what the difference is. The 56cm domane has exactly the same reach as the giant, while the 54cm is 2cm shorter. Question is should this be the priority over stack? The 56cm domane is certainly taller but that can be changed with stem spacers can’t it? Fewer spacers would bring the actual riding position into a similar place as on the giant, wouldn’t it? Advice would be welcomed! The geometry comparison is in the image.
Thanks!

Thanks!

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Good thing I’m not a maths teacher or anything... ahem. Think I’m persuading myself to pull the trigger.
Anyway, do you know your fit numbers? I know they're not the be all and end all, but I had my custom frame built around being able to run the frame with no spacers under a 100mm stem.
I would look at what stem and spacer setup each results in and see if you're happy. There's a good website I found which calculates all this for you: http://www.bikegeo.net/
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Going to have a look at that link now
54 cm and 56 cm treks have almost exactly the same reach (as does the Giant) - you aren't going to notice 3 mm - there is more variation between different brands of bar tape. So if you go by stack and reach, the only difference should be that you are more upright on the 56 cm, right? You can fix that with fewer spacers, you'd think.
But reach doesn't take into account what's going on behind the vertical line with the BB. With the Treks, the 56 cm has slacker frame angles, so your bum will end up quite a bit further back, and the distance from the top of the seat post to the bars will be somewhere around 1.5-2 cm range longer, which is quite a bit.
So, assuming your two bikes fit nicely, I'm going to say the 56 is too big for you. You will be forever trying to push the saddle further forward and lower the bars - by about 1-2 cm each.
And if you think you are between sizes, the smaller one is the size to go for.
The seat mast thing might be a red herring, btw - the previous owner may have cut it to size.
Years ago I got a couple of second hand bikes. I needed a traditional 56 (normally comes up as a 55 on more modern charts). Convinced myself a 58 would do. Felt fine in the shop and round the car park I thought. Different matter 30 miles into a hilly ride. I used that bike all through uni with an 8 cm stem and the saddle rammed forward, because I needed a 56. So, I'd question the wisdom of being like me!!
However adding spacers to the 54 would shorten the reach for an equivalent stack to the 56.
In practice you end up adjusting saddle to the bars, that's my point.
Re to the part of the bike behind the BB was merely to point out that reach does not take it into account at all. Which is fine unless you are one of those cyclists who sit down.
And the line between the BB and the seat is a hell of a lot longer than a couple of spacers. So there's a bit fat unknown in terms of fit if you only look at stack and reach.
Personally, I'm not very sensitive to differences in reach, as between two bike that fit. Perhaps some people are, I don't know.
Stack seems to make a bit more sense for comparisons though, I'll admit. And that 56 looks a lot more upright to me.