Does Di2 need indexing?

Hi all.

Asking this as I thought it didn't but recently I've noticed on my canyon aeroad that when in big ring and moving through gears on cassette it starts "clicking"

It's as if it's trying to get into the gear but can't, havnt had this before untill recently after I cleaned bike and wondering if there a way to sort this with di2?

Any help be great cheers