Smart trainers and poor indexing?

Just wondering if people find they need to change their indexing much on the bike they use with their smart trainer? I use my previous winter/poor weather bike which has Ultegra on it - all in good condition; I've checked for wear etc. However, after 3-4 weeks I find I need to play around with the indexing as the gears won't change smoothly. I use this bike on a Wahoo Kickr and wonder if it has anything to do with the bike being in a relatively fixed position with 'different' forces acting through the rear aspect of the bike frame? I never seemed to have to do this when I used it as a winter/poor weather bike.
Thoughts? Similar experiences?
Thoughts? Similar experiences?
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regarding the Kickr, this was a previous version, I don't know it was correct in the latest model but it was the reason I sent mine back.
I've worked out that it's down to how tight you do up the QR skewer.
I seem to do mine up tighter on the turbo than on a road wheel and that changes the position of the mech hanger
If I change to etap , I am free of this obsession unless some smart alec comes up with a theory.
Wahoo are probably not concerned with cheapskates who cannot leave a Dogma permanently attached to one of their turbos.
Colnago C59 on mine