Reindexing when on/off Turbo??

I replaced Wheels, cables, cassette, chain and inner ring in the past couple of weeks.
I replaced like for like, same 10 speed cassette, same ratios etc.
I've got a strange dilemma, that I wonder if anyone else has experienced.
When I have the bike perfectly set up and indexed, it rides fine on the road (some minor adjustments yesterday, but putting that down to cable stretch)
When I then replace the skewer and put the bike on the turbo .. the indexing is out of whack.
When I index the bike on the turbo .. it's fine .... when I take it off and replace the skewer.... knackered again.
I've checked everything .. stripped the cassette off again .. double checked the spacer required was on the wheel... all looks good.
Anybody out there had this??
I replaced like for like, same 10 speed cassette, same ratios etc.
I've got a strange dilemma, that I wonder if anyone else has experienced.
When I have the bike perfectly set up and indexed, it rides fine on the road (some minor adjustments yesterday, but putting that down to cable stretch)
When I then replace the skewer and put the bike on the turbo .. the indexing is out of whack.
When I index the bike on the turbo .. it's fine .... when I take it off and replace the skewer.... knackered again.
I've checked everything .. stripped the cassette off again .. double checked the spacer required was on the wheel... all looks good.
Anybody out there had this??
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I have the same issue with my Kickr, I have to slightly adjust the rear derailleur when swapping on or off the trainer and putting the wheel in.
@Bigmitch_racing
2010 Specialized Tricross (commuter)
2014 Whyte T129-S
2016 Specialized Tarmac Ultegra Di2
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