Road bike sizing for tall rider?

I'm looking to buy a road bike, and sizing seems more critical than in mtb- I usually ride a 13.5" jump bike, 16" freeride rig and 20" XC bike.
I'm 6'7", and that apparently equates to a road frame size of about 25". As I'm looking to buy secondhand, this kind of size is quite difficult to find, so I was wondering, is a 25" frame an optimum size, or a necessary one? can I go down to maybe 23" or 24" without it being dangerously small, or just plain painful to ride, or is a 25" frame the only realistic option?
Also, can someone please explain wheels sizes? I've seen everything from 26" to 28" to 700c? :? just a bit confusing to the beginner in this discipline of riding
Thanks
I'm 6'7", and that apparently equates to a road frame size of about 25". As I'm looking to buy secondhand, this kind of size is quite difficult to find, so I was wondering, is a 25" frame an optimum size, or a necessary one? can I go down to maybe 23" or 24" without it being dangerously small, or just plain painful to ride, or is a 25" frame the only realistic option?
Also, can someone please explain wheels sizes? I've seen everything from 26" to 28" to 700c? :? just a bit confusing to the beginner in this discipline of riding

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Most wheels these days are 700c (also, most frames are now in cm and you will probably be looking at at least a 61 or 62cm).
Wheels on modern road bikes are 700c. MTBs have 26" I think....
My advice would-be to find your local LBS and sit on one. You need to know whats comfortable for you, were all different
Find a bike shop that has a big stock of demo bike and give some a try, it'll be pretty obvious if they are too small for you.
Fun: Yeti SB66
Road: Litespeed C1, Cannondale Supersix Evo, Cervelo R5
Trainer: Bianchi via Nirone
Hack: GT hardtail with Schwalbe City Jets
Good luck!
I wear size 45 (10.5-11) shoes and only had problems hitting the rear mech before I replaced the original pedals that weren't suitable for larger feet being a one size fits all.
Mind you I get the impression that height vs frame size is more a case of Leg length vs torso length vs frame size.
I have found that regardless of the advertised "size", bikes with a top tube of less than 59cm are a no-go area for me.
Big H
May the road rise up to meet you.
May the wind always be at your back.
The downsides of buying new would obviously be getting a much lower-spec bike and taking a much larger depreciation hit.