changing rear wheels

hi folks,
this may be a silly question..... but....
If i change the rear wheel on my bike to a wheel with a different size cassette do i have to adjust the rear derailleur?
this may be a silly question..... but....
If i change the rear wheel on my bike to a wheel with a different size cassette do i have to adjust the rear derailleur?
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Where the cassette might mean you need to adjust the rear mech is in the B-tension screw, if you swap to a much bigger cassette and find that the mech cage is rubbing on the big cog.
You might have to fine-adjust the rear mech slightly so it engages the gears cleanly, and to adjust the top/bottom end-stops slightly, but that would be due to changing the wheel to one with slightly different dishing/axle adjustment rather than because of the different cassette.
You might be lucky and need no adjustment, I have two sets of wheels which I swap around between my best bike and TT bike and they need no adjustment.
You might need to adjust the chain length : if you were changing from say a 12-21 cassette to a 12-27, then you'll need a longer chain.
But say 12-23 to 12-25 or 12-25 to 12-27 you probably won't.
If you want to fit a really low MTB cassette, like a 11-32, onto a roadbike fitted with a short-cage rear mech, then you'll need a new rear mech.