Numb feet = saddle issues?

I've had my road bike (a Claud Butler Roubaix) for about 6 months, and for as long as I've started riding longer distances (ie this summer), my feet always go numb.
I've been adjusting the bike (back pain solved by raising the saddle, shoulder, neck and wrist pain solved by twisting the handlebars upwards) according to advice from my LBS, but this is one issue I can't seem to get rid of, no matter what I change on the bike.
During the week, I mainly use my bike to commute to training, about 6 miles each way, and work, about 16 miles each way, and there's no difference between using flats or SPDs. I loosen my shoes about 3 miles, but the relief is minimal.
The only thing I can think of is my saddle providing insufficient support, but I'm unsure whether this can cause numbness. I know it's worth going to get measured for a saddle anyway, but has anyone else experienced this and if so, any idea what may be causing it?
I've been adjusting the bike (back pain solved by raising the saddle, shoulder, neck and wrist pain solved by twisting the handlebars upwards) according to advice from my LBS, but this is one issue I can't seem to get rid of, no matter what I change on the bike.
During the week, I mainly use my bike to commute to training, about 6 miles each way, and work, about 16 miles each way, and there's no difference between using flats or SPDs. I loosen my shoes about 3 miles, but the relief is minimal.
The only thing I can think of is my saddle providing insufficient support, but I'm unsure whether this can cause numbness. I know it's worth going to get measured for a saddle anyway, but has anyone else experienced this and if so, any idea what may be causing it?
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According to Bicycling Medicine, another possible cause is arthritis.
As for the shoes being too tight, it's happened to me with trainers and other shoes as well, but how do you establish proper sizing for cycling shoes? Mine are 1/2 size bigger than I generally buy, and I normally wear Sealskinz waterproof socks which are fairly thick, but I can walk around in them comfortably for ages. Also, they're MTB shoes, which I'd have thought would be more flexible and reduce numbness?
If you decide to move the cleats, Bicycling Medicine suggests, "Usually the cleat needs to be placed farther back, although solutions differ.".