Two sets of wheels OK with disc brakes?

Bit of a newb question but currently I cycle some on-road and off-road stuff on my MTB but am getting fed up changing tires 2 or 3 times a week 
If I get a new set of wheels with disc hubs + rotor will it align perfectly with the calipers set for my existing wheels or will I potentially need to adjust my caliper positions each time I change wheels (which would be as much hassle as changing tires). If they should line up exactly would the same be true if I got a centre-lock hub + adaptor for the rotor (just I know somewhere selling XT wheelsets cheap but they are centre lock disc hubs only).
Also my existing wheels have a SRAM 9-spd cassette (but XT shifters, mech and HG73 chain) if I did get another set of wheels should I also get a SRAM cassette or can I get an XT cassette (which are also on sale
)?

If I get a new set of wheels with disc hubs + rotor will it align perfectly with the calipers set for my existing wheels or will I potentially need to adjust my caliper positions each time I change wheels (which would be as much hassle as changing tires). If they should line up exactly would the same be true if I got a centre-lock hub + adaptor for the rotor (just I know somewhere selling XT wheelsets cheap but they are centre lock disc hubs only).
Also my existing wheels have a SRAM 9-spd cassette (but XT shifters, mech and HG73 chain) if I did get another set of wheels should I also get a SRAM cassette or can I get an XT cassette (which are also on sale

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