Advice on first 'proper' road bike

Hi all.
I'm in the process of selling my Specialized TriCross (58 cm 2011 model - on that famous auction site until Sun 6th Jan if anyone's interested) which has served me well over the past two years, but I'm now looking to step up to a 'proper' road bike. I mainly intend to use it for 2-3 hour rides at weekends, sportives & occassional multi-day efforts like the c2c (which I did last summer on the TriCross), so the emphasis will be more on comfort than pace, but an increase in speed/performance from the TriCross would be very welcome. I'm 6'3" with a 36" inside leg so will need a largish frame.
Having done a fair bit of research on-line, I've come up with a shortlist of the following:
Cannondale CAAD10 (105 groupset, Tektro R580 brakes, Shimano RS10 wheels)
Cube Agree GTC Pro (105/Ultegra groupset, Shimano BR-R561 brakes, Mavic Aksium 5 wheels)
Giant Defy 1 (105 groupset, Tektro R540 brakes, Giant P-R2 wheels)
Specialized Roubaix Sport (105 groupset, 105 brakes, DT Axis 1 wheels)
Trek Madone 3.1 C H2 (105/Tiagra groupset, 105 brakes, Bontrager wheels)
The above is mainly based on reviews, price (all pretty similar apart from Defy which is £200-300 cheaper) & availability at my LBS. As you can probably tell, I've not yet decided whether to go for a better spec alu frame (Cannondale & Giant) or a lower spec carbon frame (others). Of the latter, the Cube sticks out as the best spec (I think), although the 2013 models seem to have a poorer spec than their 2012 equivalents. I have read comments from a few people that the Cannondale geometry may not be so well suited to my intended use, but the BikeRadar/CyclingPlus review (http://www.bikeradar.com/gear/category/ ... 5-12-45526) suggests it may have enough comfort for long rides. So this could be one to chop from the list, along with the Roubaix which I've read does have a somewhat over-relaxed geometry that wouldn't be so suited to spontaneous impersonations of Mark Cavendish.
I was hoping to further narrow the list down to 2-3 before popping down to my LBS. Any thoughts on the above?
Any advice would be greatly received. Thanks.
I'm in the process of selling my Specialized TriCross (58 cm 2011 model - on that famous auction site until Sun 6th Jan if anyone's interested) which has served me well over the past two years, but I'm now looking to step up to a 'proper' road bike. I mainly intend to use it for 2-3 hour rides at weekends, sportives & occassional multi-day efforts like the c2c (which I did last summer on the TriCross), so the emphasis will be more on comfort than pace, but an increase in speed/performance from the TriCross would be very welcome. I'm 6'3" with a 36" inside leg so will need a largish frame.
Having done a fair bit of research on-line, I've come up with a shortlist of the following:
Cannondale CAAD10 (105 groupset, Tektro R580 brakes, Shimano RS10 wheels)
Cube Agree GTC Pro (105/Ultegra groupset, Shimano BR-R561 brakes, Mavic Aksium 5 wheels)
Giant Defy 1 (105 groupset, Tektro R540 brakes, Giant P-R2 wheels)
Specialized Roubaix Sport (105 groupset, 105 brakes, DT Axis 1 wheels)
Trek Madone 3.1 C H2 (105/Tiagra groupset, 105 brakes, Bontrager wheels)
The above is mainly based on reviews, price (all pretty similar apart from Defy which is £200-300 cheaper) & availability at my LBS. As you can probably tell, I've not yet decided whether to go for a better spec alu frame (Cannondale & Giant) or a lower spec carbon frame (others). Of the latter, the Cube sticks out as the best spec (I think), although the 2013 models seem to have a poorer spec than their 2012 equivalents. I have read comments from a few people that the Cannondale geometry may not be so well suited to my intended use, but the BikeRadar/CyclingPlus review (http://www.bikeradar.com/gear/category/ ... 5-12-45526) suggests it may have enough comfort for long rides. So this could be one to chop from the list, along with the Roubaix which I've read does have a somewhat over-relaxed geometry that wouldn't be so suited to spontaneous impersonations of Mark Cavendish.
I was hoping to further narrow the list down to 2-3 before popping down to my LBS. Any thoughts on the above?
Any advice would be greatly received. Thanks.

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Giant Defy 1 (105 groupset, Tektro R540 brakes, Giant P-R2 wheels)
they are quite different kind of bikes. are they comparible?
http://chup.info/c/tag/trek/
Other than that, all are pretty well regarded bikes from what I've read.
http://www.edinburghbicycle.com/product ... us-apex-13
This is a sportive frame with decent groupset and gearing range. if you buy via fat Birds you can spec the bike to your requirements i.e. 105, campag etc. The bike is a modern version of the Mistral and Euros both of which got great reviews in the past.
I bought the SL3/Ultegra version this year and still have my CAAD5/Dura Ace (won't be that different from CAAD10). I run the same set of wheels on both bikes so can make a good comparison.
There's little in it weight wise and both are beautifully finished. The CAAD5 with tyres at 110psi transmits a lot of road noise and has a racier position, but it's a nice bike. The Roubaix is stunningly good, with tyres at 120psi it's like a magic carpet and just glides over bad surfaces. My nephew noticed that I no longer try and avoid small potholes and the like. The position isn't too upright but it's very comfy as are the larger diameter handle bars and the superb Toupe BG saddle.
I did a seven hour ride on the Roubaix and only my legs were sore, best money I ever spent. If I won the lottery tomorrow I'd still ride it.
You're betting comparing a carbon Synapse than the CAAD10. I wanted one of those originally but the bike shop at the end of my road is a Specialized dealer and I wasn't going anywhere else.
Specialized Roubaix SL3 Expert 2012, Cannondale CAAD5,
Marin Mount Vision (1997), Edinburgh Country tourer, 3 cats!